This document is issued jointly by the NTG and the HealthMatters Program as part of an advisory series on risk reduction in adults with intellectual disability and promoting healthy brain outcomes. We recognize that in some instances overmedicating can have negative consequences on physical and brain health, as well as potentially increase the risk for mild cognitive impairment or dementia. We hope that the information provided will lead to constructive scrutiny of medication use, avoid ‘medication harm’, and result in safer medication use and positive health outcomes.Â